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NPR's Robert Siegel speaks with political consultant Doug Cole, of High Ground, about how Sen. Flake's announcement is dramatically changing the political landscape in Arizona. He says it's having a cascading effect as Arizona lawmakers, who would never consider running against Flake, weigh getting into the primary race.

Vice President Pence cast the tie-breaking vote last night in the Senate to repeal a rule that made it easier for Americans to sue their banks and credit card companies for wrongdoing. Wiping out the rule affects tens of millions of Americans who will be sent to arbitration on disputes over a credit card, checking account or prepaid card. It also dismantles the work of the Consumer Financial Protection Bureau, which has been working on this for years.

An influential Harlem church is trying to help the National Institutes of Health overcome reluctance by some African-Americans to participate in a medical study of 1 million diverse Americans.

After a two-year battle between "Keepers," who want the name to stay, and "Changers," who believe it represents the history of racism, the board is expected to remove the name Thursday.

Republican Arizona Senator Jeff Flake announces he won’t run for re-election, denounces Trump and warns the GOP on its direction.

The U.S. Fish and Wildlife Service has banded together with five conservation groups to offer a reward for information about the killing of a federally protected gray wolf.

The appointment of retired Col. Noel Zamot comes after a controversial $300 million contract to rebuild the island's power grid was awarded to a tiny company with little experience.

The former president "has patted women's rears in what he intended to be a good-natured manner," his spokesman wrote. Actress Heather Lind wrote that Bush "sexually assaulted" her.

Rosa Maria Hernandez, who came illegally to the U.S. from Mexico when she was 3 months old, was being transferred between hospitals in Texas when the ambulance was stopped by federal officers.

The commission is facing eight lawsuits and one Republican member says, "We're not emailing each other. We're not conversing with each other."